Application Cases

In medicine, there are many methods for the delivery of topical medications. Traditional oral administration and syringe-based drug delivery, while simple to operate and highly efficient in drug delivery, also have drawbacks such as significant side effects and low patient compliance. Transdermal drug delivery is one of the promising alternatives to oral administration and syringe injections. Moreover, transdermal drug delivery directly targets the affected area of the patient, greatly enhancing treatment efficacy. Current drug delivery technology combines ultrasound-assisted penetration and microneedle-assisted penetration techniques, utilizing the vibrational energy generated by ultrasound to promote drug penetration into the body for therapeutic purposes. This technology can reduce patient pain and minimize drug consumption, improving treatment efficiency.

Regarding experimental research in low-frequency ultrasound, Aigtek's ATA-2000 series high-voltage amplifiers have widespread applications in this field. They can output a maximum of 1600 Vpp AC voltage, capable of driving most low-frequency ultrasonic transducers.

Experimental Name: Transdermal Drug Delivery Experiment Using an Ultrasound Microneedle Array System

Experimental Principle:
Ultrasound promotes transdermal drug delivery through three mechanisms: cavitation effect, thermal effect, and mechanical effect. The cavitation effect involves gas molecules within tissue cells forming tiny bubbles under ultrasound action, which gradually grow and eventually rupture, creating pores in the stratum corneum to enhance transdermal drug delivery efficiency. The thermal effect refers to the localized temperature increase in the skin due to ultrasonic energy, leading to pore enlargement and increased skin permeability, thereby enhancing transdermal drug delivery efficiency. The mechanical effect involves high-frequency ultrasonic vibrations transmitted to the skin, causing intense vibration of internal skin particles, which enhances skin permeability and improves transdermal drug delivery efficiency. Among these, the ultrasound cavitation effect plays a primary role in promoting transdermal drug delivery.

Experimental Block Diagram:

Experimental Setup Image:

Experimental Procedure:
First, a sine wave voltage signal is generated using a signal generator and amplified by the Aigtek ATA-2041 high-voltage power amplifier. This provides voltage to the ultrasound microneedle array module. The dosage module includes a micro-injection pump, which ensures stable and precise control of micro-quantities of the drug solution. The displacement module consists of a stepper motor controller and an electric slider, accurately controlling the penetration depth of the hollow microneedles in the ultrasound microneedle array module. Drug delivery is achieved through the vibration of the microneedles.

Application Areas: Biomedical field, ultrasonic medical field, 3D printing technology

Application Scenarios: Drug delivery, drug toxicity testing, subcutaneous drug control, optical fiber vibration testing, etc.

Recommended Product：ATA-2000 Series High-Voltage Amplifier Specifications